Local Haemostasis and Soft Tissue Regeneration

The Local Haemostasis and Soft Tissue Regeneration research group focuses on the targeted, effective, and appropriate treatment of acute injuries, intraoperative bleeding, and chronic wounds. Its work centres on the development of novel haemostatic agents and innovative strategies to promote tissue healing. The scope ranges from molecular mechanisms and biomaterial development to biophysical therapies and clinical applications.

A key area of research is wound sealing using biological and synthetic materials. Central to this is fibrin, the final product of the body’s natural coagulation cascade, which forms the basis for advanced tissue adhesives. These adhesives enable rapid bleeding control, offer excellent biocompatibility, and are naturally resorbed by the body. The group is also involved in developing corresponding application devices for clinical use.

In addition to optimising local haemostasis, the group is also dedicated to promoting soft tissue regeneration. One particular focus is the use of non-invasive physical therapies that positively influence wound healing. Among these, extracorporeal shock wave therapy (ESWT) is of particular interest. Research has shown that it can significantly stimulate the regeneration of bone and soft tissue, for example by promoting the recruitment of stem cells to the wound site. Today, shock wave therapy is standard practice in AUVA trauma hospitals, especially for treating complex fractures and slow-healing wounds.

Austria’s global leadership in the treatment of non-healing bone fractures is due in part to the pioneering work of Wolfgang Schaden, former senior consultant at the Trauma Centre Vienna, Meidling. He is regarded as a pioneer in the field of shock wave research in traumatology. His groundbreaking studies at LBI Trauma and AUVA led to the founding of the European, and later the International Society for Medical Shockwave Treatment (ISMST).

The Austrian broadcaster ORF III dedicated a 45-minute documentary to the healing power of shock waves in its programme Treffpunkt Medizin. With kind permission from ORF, the programme is available for viewing on our website.