The major research focus is the development of methods for quantitative analysis of biological systems at the nanoscale. Our group has long-time experience in single molecule fluorescence microscopy, force microscopy as well as 2D/3D nanolithography. By precisely localising and measuring the dynamics of biomolecules and determining molecular interactions, we seek to understand their function in model systems as well as in living cells. We are currently engaged in method development for the characterisation and understanding of physical properties of individual cells, nanobioparticles or lipids and proteins. Another important aspect of our work is the application of our research to the development of device technologies and image processing tools.
Strohmeier K, Hofmann M, Hauser F, Sivun D, Puthukodan S, Karner A, Sandner G, Le Renard PE, Jacak J, Mairhofer M (2021). CRISPR/Cas9 Genome Editing vs. Over-Expression for Fluorescent Extracellular Vesicle-Labeling: A Quantitative Analysis. Int J Mol Sci. 2021 Dec 28;23(1):282.
Priglinger E, Strasser J, Buchroithner B, Weber F, Wolbank S, Auer D, Grasmann E, Arzt C, Sivun D, Grillari J, Jacak J, Preiner J, Gimona M (2021). Label-free characterization of an extracellular vesicle-based therapeutic. J Extracell Vesicles. 2021 Oct;10(12):e12156.