In his research, Johannes focuses on EVs derived from endothelial cells. He aims to characterize them in sophisticated manners to enable their future use in clinical research and to subsequently investigate the role of these cell-derived particles in the intercellular communication between blood and lymphatic vasculature to shed light on physiological and pathological processes linked to them. The application of EVs in the treatment of lymphedema thereby is one of the main goals and motivation for his research.