Monitoring

Monitoring

The complex pathophysiological processes in the first hours and days after trauma are essential for the development of posttraumatic complications and multiple organ failure (MOF). Therefore, a quick and reliable clinical diagnosis is one of the greatest challenges for the management of trauma patients.

The group around Soheyl Bahrami works on the characterization of various potential pathophysiological risk factors. This includes for example haemorrhage, coagulopathy, traumatic brain injury, inflammation or infection. In trauma patients it is essential to improve the outcome of these risk factors. The research focuses currently on:

  • Immune status (Inflammatory response)
  • Haemostasis (thromboelastometry vs. standard coagulation tests)
  • Septic complications (prediction, risk stratification)
  • Traumatic Brain Injury (circulating biomarkers)
  • Gut (permeability changes, bacterial translocation)
  • Bedside Monitoring (POCT development, new testing methods)

The research group aims at improving diagnostic measures that optimize the clinical decision making process. Through that, individualized therapies for trauma patients can be provided and the therapeutic efficacy and outcome can be improved.

Selected Publications

Hochleitner G, Sutor K, Levett C, Leyser H, Schlimp CJ, Solomon C (2017). Revisiting Hartert’s 1962 Calculation of the Physical Constants of Thrombelastography. Clin Appl Thromb Hemost, 23(3):201-210.
(free PDF)

Zirath H, Schnetz G, Glatz A, Spittler A, Redl H, Peham JR (2017). Bedside Immune Monitoring: An Automated Immunoassay Platform for Quantification of Blood Biomarkers in Patient Serum within 20 Minutes. Anal Chem, 89(9):4817-4823.

Zirath H, Peham JR, Schnetz G, Coll A, Brandhoff L, Spittler A, Vellekoop MJ & Redl H (2016). A compact and integrated immunoassay with on-chip dispensing and magnetic particle handling. Biomed Microdevices, 18(1):16.

Zhang LA1, Parker RS, Swigon D, Banerjee I, Bahrami S,  Redl H & Clermont G (2016). A One-Nearest-Neighbor Approach to Identify the Original Time of Infection Using Censored Baboon Sepsis Data. Crit Care Med, 44(6):e432-442.
(free PDF)

Solomon C, Schöchl H, Ranucci M & Schlimp CJ (2015). Can the Viscoelastic Parameter α-Angle Distinguish Fibrinogen from Platelet Deficiency and Guide Fibrinogen Supplementation? Anesth Analg, 121(2):289-301.

Schlimp CJ, Khadem A, Klotz A, Solomon C, Hochleitner G, Ponschab M, Redl H & Schöchl H (2015). Rapid measurement of fibrinogen concentration in whole blood using a steel ball coagulometer. J Trauma Acute Care Surg, 78(4):830-836.
(free PDF)

Solomon C, Schöchl H, Ranucci M, Schött U & Schlimp CJ (2015). Comparison of fibrin-based clot elasticity parameters measured by free oscillation rheometry (ReoRox ®) versus thromboelastometry (ROTEM ®). Scand J Clin Lab Invest, 75(3):239-246.
(free PDF)

Herwig E, Marchetti-Deschmann M, Wenz C, Rüfer A, Redl H, Bahrami S & Allmaier G (2015). Sensitive detection of C-reactive protein in serum by immunoprecipitation-microchip capillary gel electrophoresis. Anal Biochem, 478:102-106.

Schlimp CJ, Solomon C, Ranucci M, Hochleitner G, Redl H & Schöchl H (2014). The effectiveness of different functional fibrinogen polymerization assays in eliminating platelet contribution to clot strength in thromboelastometry. Anesth Analg, 118(2):269-276.

Schöchl H, Schlimp CJ & Voelckel W (2014). Perioperative coagulation management in multiple trauma patients based on viscoelastic test results. Unfallchirurg, 117(2):111-117.

Zipperle J, Schlimp CJ, Holnthoner W, Husa AM, Nürnberger S, Redl H & Schöchl H (2013). A novel coagulation assay incorporating adherent endothelial cells in thromboelastometry. Thromb Haemost, 109(5):869-877.

Schöchl H, Solomon C, Laux V, Heitmeier S, Bahrami S & Redl H (2012). Similarities in Thromboelastometric (ROTEM®) Findings between Humans and Baboons. Thromb Res, 130(3):e107-e112.

Sobhian B, Kröpfl A, Hölzenbein T, Khadem A, Redl H & Bahrami S (2012). Increased Circulating D-Lactate Levels Predict Risk of Mortality After Hemorrhage and Surgical Trauma in Baboons. Shock, 37(5):473-477.

Schöchl H, Solomon C, Schulz A, Voelckel W, Hanke A, Van Griensven M, Redl H & Bahrami S (2011). Thromboelastometry (TEM®) Findings in Disseminated Intravascular Coagulation in a Pig Model of Endotoxinemia. Mol Med, 17(3-4):266-272.
(free PDF)

Drechsler S, Weixelbaumer KM, Redl H, van Griensven M, Bahrami S & Osuchowski MF (2011). Experimentally approaching the ICU: monitoring outcome-based responses in the two-hit mouse model of posttraumatic sepsis. J Biomed Biotechnol, 2011:357926.

Bahrami S, Pelinka L, Khadem A, Maitzen S, Hawa G, van Griensven M & Redl H (2010). Circulating NT-proCNP predicts sepsis in patients with multiple trauma. Critical Care Medicine, 38(1):161-166.

Assadian A, Assadian O, Senekowitsch C, Rotter R, Bahrami S, Furst W, Jaksch W, Hagmuller GW & Hubl W (2006). Plasma d-Lactate as a Potential Early Marker for Colon Ischaemia After Open Aortic Reconstruction. Eur J Vasc Endovasc Surg, 31(5):470-474.

Pelinka LE, Hertz H, Mauritz W, Harada N, Jafarmadar M, Albrecht M, Redl H & Bahrami S (2005). Nonspecific increase of systemic neuron-specific enolase after trauma: clinical and experimental findings. Shock, 24(2):119-123.

Pelinka LE, Jafarmadar M, Redl H & Bahrami S (2004). Neuron-specific-enolase is increased in plasma after hemorrhagic shock and after bilateral femur fracture without traumatic brain injury in the rat. Shock, 22(1):88-91.

Pelinka LE, Schmid-Hammer R, Redl H & Bahrami S (2004). Release of neuron-specific enolase and s100 after implantation of cardioverters/defibrillators. Crit Care Med, 32(4):1093-1094.

Pelinka LE, Harada N, Szalay L, Jafarmadar M, Redl H & Bahrami S (2004). Release of S100B differs during ischemia and reperfusion of the liver, the gut, and the kidney in rats. Shock, 21(1):72-76.

Szalay L, Umar F, Khadem A, Jafarmadar M, Furst W, Ohlinger W, Redl H & Bahrami S (2003). Increased plasma D-lactate is associated with the severity of hemorrhagic/traumatic shock in rats. Shock, 20(3):245-250.

Pelinka LE, Szalay L, Jafarmadar M, Schmidhammer R, Redl H & Bahrami S (2003). Circulating S100B is increased after bilateral femur fracture without brain injury in the rat. Br J Anaesth, 91(4):595-597.

Pelinka LE, Bahrami S, Szalay L, Umar F & Redl H (2003). Hemorrhagic shock induces an S 100 B increase associated with shock severity. Shock, 19(5):422-426.

Junger W, Junger WG, Miller K, Bahrami S, Redl H, Schlag G & Moritz E (1996). Early detection of anastomotic leaks after colorectal surgery by measuring endotoxin in the dranage fluid. Hepato-Gasteroenterologie, 43(12):1523-1529.

Strohmaier W, Bahrami S, Davis J, Redl H & Schlag G (1991). Neopterin and tumor necrosis factor- α: Two markers of monoyte/macrophge activation in a septic baboon model. Pteridines, 3(3):181-184.