Hard tissue histology is a method that is used to visualize and analyze the structures of hard tissues. Unlike in soft tissues the extracellular matrix of hard tissues as bones and teeth is mineralized and it is therefore impossible to process them with conventional histologic methods.
Accordingly the research group of Stefan Tangl employs specialized techniques to examine changes in hard tissues and to describe and quantify their regeneration. For instance it is tested if the application of growth factors or of cells breed in cell cultures leads to an increase in bone regeneration and improves the integration of implant and bone substitute materials.
The following techniques are used:
- Cutting–Grinding Technique to produce and analyze undecalcified histological thin-ground sections
- Histomorphometry to measure bone tissue and biomaterials
- Analysis of microCT scans and 3D reconstructions (high-resolution three-dimensional visualization of bone structure and regeneration)
The aim is to develop new therapeutic strategies to optimize the integration of biomaterials.
Furthermore, the research focus is put on improving bone supply by using and testing bone substitute materials to regenerate bone.