Darja Marolt Presen
PhDResearch interests:
My main research interests involve bone regeneration with an emphasis on stem cell research, cell aging/rejuvenation and tissue engineering.
Previous positions:
2014-2015 Visiting Professor
Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria
2012-2013 Visiting Scientist
Educell d.o.o., Trzin, Slovenia
2010-2013 NYSCF-Helmsley Investigator, Group Leader,
The New York Stem Cell Foundation, New York, USA
2010-2012 Adjunct Associate Research Scientist
Department of Biomedical Engineering, Columbia University, New York, USA
Education:
2006-2010 Postdoctoral Research Scientist/Fellow
Department of Biomedical Engineering, Columbia University, New York, USA
2004-2005 Visiting Graduate Student
MIT-Harvard Division of Health Sciences and Technology, Massachusetts Institute of Technology, Boston, USA
2002-2005 Graduate Researcher
Blood Transfusion Centre of Slovenia, Ljubljana, Slovenia
2001-2006 Ph.D. in Biotechnology
Biotechnical Faculty, University of Ljubljana, Ljubljana, Slovenia
1995-2001 B.Sc. in Microbiology
Biotechnical Faculty, University of Ljubljana, Ljubljana, Slovenia
Selected Publications
Effects of Endochondral and Intramembranous Ossification Pathways on Bone Tissue Formation and Vascularization in Human Tissue-Engineered Grafts.
Bernhard JC, Marolt Presen D, Li M, Monforte X, Ferguson J, Leinfellner G, Heimel P, Betti SL, Shu S, Teusch-Woller AH, Tangl S, Redl H, Vunjak-Novakovic G.
Cells. 2022 Sep 29;11(19):3070. doi: 10.3390/cells11193070. PMID: 36231032
Increased Exhaustion of the Subchondral Bone-Derived Mesenchymal Stem/ Stromal Cells in Primary Versus Dysplastic Osteoarthritis.
Čamernik K, Mihelič A, Mihalič R, Marolt Presen D, Janež A, Trebše R, Marc J, Zupan J.
Stem Cell Rev Rep. 2020 Aug;16(4):742-754. doi: 10.1007/s12015-020-09964-x. PMID: 322005053
A novel fluorescent hydroxyapatite based on iron quantum cluster template to enhance osteogenic differentiation.
Hashemi N, Vaezi Z, Khanmohammadi S, Naderi Sohi A, Masoumi S, Hruschka V, Wolbank S, Redl H, Marolt Presen D, Naderi-Manesh H.
Mater Sci Eng C Mater Biol Appl. 2020 Jun;111:110775. doi: 10.1016/j.msec.2020.110775. Epub 2020 Feb 24. PMID: 32279758
Comprehensive analysis of skeletal muscle- and bone-derived mesenchymal stem/stromal cells in patients with osteoarthritis and femoral neck fracture.
Čamernik K, Mihelič A, Mihalič R, Haring G, Herman S, Marolt Presen D, Janež A, Trebše R, Marc J, Zupan J.
Stem Cell Res Ther. 2020 Apr 3;11(1):146. doi: 10.1186/s13287-020-01657-z. PMID: 32245507 Free PMC article.
Mesenchymal Stromal Cell-Based Bone Regeneration Therapies: From Cell Transplantation and Tissue Engineering to Therapeutic Secretomes and Extracellular Vesicles.
Marolt Presen D, Traweger A, Gimona M, Redl H.
Front Bioeng Biotechnol. 2019 Nov 27;7:352. doi: 10.3389/fbioe.2019.00352. eCollection 2019. PMID: 31828066 Free PMC article. Review.
Make no bones about it: cells could soon be reprogrammed to grow replacement bones?
de Peppo GM, Marolt D.
Expert Opin Biol Ther. 2014 Jan;14(1):1-5. doi: 10.1517/14712598.2013.840581. Epub 2013 Sep 23.
Engineering bone tissue substitutes from human induced pluripotent stem cells.
de Peppo GM, Marcos-Campos I, Kahler DJ, Alsalman D, Shang L, Vunjak-Novakovic G, Marolt D.
Proc Natl Acad Sci U S A. 2013 May 21;110(21):8680-5. doi: 10.1073/pnas.1301190110. Epub 2013 May 7.
Bioreactor engineering of stem cell environments.
Tandon N, Marolt D, Cimetta E, Vunjak-Novakovic G.
Biotechnol Adv. 2013 Nov 15;31(7):1020-31. doi: 10.1016/j.biotechadv.2013.03.007. Epub 2013 Mar 24. Review.
Bone scaffold architecture modulates the development of mineralized bone matrix by human embryonic stem cells.
Marcos-Campos I, Marolt D, Petridis P, Bhumiratana S, Schmidt D, Vunjak-Novakovic G.
Biomaterials. 2012 Nov;33(33):8329-42. doi: 10.1016/j.biomaterials.2012.08.013. Epub 2012 Aug 16.
Engineering bone tissue from human embryonic stem cells.
Marolt D, Campos IM, Bhumiratana S, Koren A, Petridis P, Zhang G, Spitalnik PF, Grayson WL, Vunjak-Novakovic G.
Proc Natl Acad Sci U S A. 2012 May 29;109(22):8705-9. doi: 10.1073/pnas.1201830109. Epub 2012 May 14.
Engineering custom-designed osteochondral tissue grafts.
Grayson WL, Chao PH, Marolt D, Kaplan DL, Vunjak-Novakovic G.
Trends Biotechnol. 2008 Apr;26(4):181-9. doi: 10.1016/j.tibtech.2007.12.009. Epub 2008 Mar 4. Review.
Bone and cartilage tissue constructs grown using human bone marrow stromal cells, silk scaffolds and rotating bioreactors.
Marolt D, Augst A, Freed LE, Vepari C, Fajardo R, Patel N, Gray M, Farley M, Kaplan D, Vunjak-Novakovic G.
Biomaterials. 2006 Dec;27(36):6138-49. Epub 2006 Aug 8.