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Darja Marolt Presen

PhD

Forschungsinteressen:

Mein Hauptforschungsinteresse gilt der Knochenregeneration mit Schwerpunkt auf Stammzellforschung, Zellalterung/-verjüngung und Tissue Engineering.

Bisherige Positionen:

2014-2015 Gastprofessorin
Ludwig Boltzmann Institut für Experimentelle und Klinische Traumatologie, Wien, Österreich

2012-2013 Gastwissenschaftlerin
Educell d.o.o., Trzin, Slowenien

2010-2013 NYSCF-Helmsley Investigator, Gruppenleiterin,
The New York Stem Cell Foundation, New York, USA

2010-2012 Adjunct Associate Research Scientist
Institut für Biomedizintechnik, Columbia University, New York, USA

Ausbildung:

2006-2010 Postdoctoral Research Scientist/Fellow
Institut für Biomedizintechnik, Columbia University, New York, USA

2004-2005 Gaststudentin
MIT-Harvard Abteilung für Gesundheitswissenschaften und Technologie, Massachusetts Institute of Technology, Boston, USA

2002-2005 Graduate Researcher
Bluttransfusionszentrum von Slowenien, Ljubljana, Slowenien

2001-2006 Ph.D. in Biotechnologie
Biotechnische Fakultät, Universität von Ljubljana, Ljubljana, Slowenien

1995-2001 B.Sc. in Mikrobiologie
Biotechnische Fakultät, Universität Ljubljana, Ljubljana, Slowenien

Ausgewählte Publikationen

A novel fluorescent hydroxyapatite based on iron quantum cluster template to enhance osteogenic differentiation.
Hashemi N, Vaezi Z, Khanmohammadi S, Naderi Sohi A, Masoumi S, Hruschka V, Wolbank S, Redl H, Marolt Presen D, Naderi-Manesh H.
Mater Sci Eng C Mater Biol Appl. 2020 Jun;111:110775. doi: 10.1016/j.msec.2020.110775. Epub 2020 Feb 24. PMID: 32279758

Increased Exhaustion of the Subchondral Bone-Derived Mesenchymal Stem/ Stromal Cells in Primary Versus Dysplastic Osteoarthritis.
Čamernik K, Mihelič A, Mihalič R, Marolt Presen D, Janež A, Trebše R, Marc J, Zupan J.
Stem Cell Rev Rep. 2020 Aug;16(4):742-754. doi: 10.1007/s12015-020-09964-x. PMID: 322005053

Comprehensive analysis of skeletal muscle- and bone-derived mesenchymal stem/stromal cells in patients with osteoarthritis and femoral neck fracture.
Čamernik K, Mihelič A, Mihalič R, Haring G, Herman S, Marolt Presen D, Janež A, Trebše R, Marc J, Zupan J.
Stem Cell Res Ther. 2020 Apr 3;11(1):146. doi: 10.1186/s13287-020-01657-z. PMID: 32245507 Free PMC article.

Mesenchymal Stromal Cell-Based Bone Regeneration Therapies: From Cell Transplantation and Tissue Engineering to Therapeutic Secretomes and Extracellular Vesicles.
Marolt Presen D, Traweger A, Gimona M, Redl H.
Front Bioeng Biotechnol. 2019 Nov 27;7:352. doi: 10.3389/fbioe.2019.00352. eCollection 2019. PMID: 31828066 Free PMC article. Review.

Make no bones about it: cells could soon be reprogrammed to grow replacement bones?
de Peppo GM, Marolt D.
Expert Opin Biol Ther. 2014 Jan;14(1):1-5. doi: 10.1517/14712598.2013.840581. Epub 2013 Sep 23.

Engineering bone tissue substitutes from human induced pluripotent stem cells.
de Peppo GM, Marcos-Campos I, Kahler DJ, Alsalman D, Shang L, Vunjak-Novakovic G, Marolt D.
Proc Natl Acad Sci U S A. 2013 May 21;110(21):8680-5. doi: 10.1073/pnas.1301190110. Epub 2013 May 7.

Bioreactor engineering of stem cell environments.
Tandon N, Marolt D, Cimetta E, Vunjak-Novakovic G.
Biotechnol Adv. 2013 Nov 15;31(7):1020-31. doi: 10.1016/j.biotechadv.2013.03.007. Epub 2013 Mar 24. Review.

Bone scaffold architecture modulates the development of mineralized bone matrix by human embryonic stem cells.
Marcos-Campos I, Marolt D, Petridis P, Bhumiratana S, Schmidt D, Vunjak-Novakovic G.
Biomaterials. 2012 Nov;33(33):8329-42. doi: 10.1016/j.biomaterials.2012.08.013. Epub 2012 Aug 16.

Engineering bone tissue from human embryonic stem cells.
Marolt D, Campos IM, Bhumiratana S, Koren A, Petridis P, Zhang G, Spitalnik PF, Grayson WL, Vunjak-Novakovic G.
Proc Natl Acad Sci U S A. 2012 May 29;109(22):8705-9. doi: 10.1073/pnas.1201830109. Epub 2012 May 14.

Engineering custom-designed osteochondral tissue grafts.
Grayson WL, Chao PH, Marolt D, Kaplan DL, Vunjak-Novakovic G.
Trends Biotechnol. 2008 Apr;26(4):181-9. doi: 10.1016/j.tibtech.2007.12.009. Epub 2008 Mar 4. Review.

Bone and cartilage tissue constructs grown using human bone marrow stromal cells, silk scaffolds and rotating bioreactors.
Marolt D, Augst A, Freed LE, Vepari C, Fajardo R, Patel N, Gray M, Farley M, Kaplan D, Vunjak-Novakovic G.
Biomaterials. 2006 Dec;27(36):6138-49. Epub 2006 Aug 8.

Link zu Publikationen