Coagulopathies – conditions in which the blood’s ability to form clots is impaired – occur in one quarter of patients at the intensive care unit, with often life-threatening consequences. They are caused by high blood loss or reactions following systemic shock, but also previous intake of anticoagulants. Hemostasis and wound closure are vitally important as soon as possible after injury. To counteract coagulopathies blood transfusion in high amounts used to be the treatment of choice. However, blood products are valuable (because essential for the treatment of certain pathologies) and may cause unwanted side effects.