MicroRNAs (miRNAs) are short, non-coding RNA fragments that play an integral role in various biological processes by regulating gene expression and protein translation. In bone, miRNAs directly affect osteogenic cell maturation and function, and thus partake in fetal skeletal development and maintenance of postnatal bone health. In a recent study performed by scientists from LBI Trauma and BOKU, they were able to identify a change in microRNA levels associated with PLS3 mutation.
PLS3 acts as a regulator in bone metabolism. The new discovery might lead to a better understanding of childhood-onset osteoporosis, since PLS3 mutations are also associated with this disease. MiRNAs could therefore serve as potential biomarkers in diagnosing and monitoring patients or even be used as targets for therapeutic applications.
The study “Unique, gender-dependent serum microRNA profile in PLS3 gene-related osteoporosis” was published in Journal for Bone and Mineral Research and has made it on the list of highlighted papers by the American Society for Bone and Mineral Research.