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Current gaps in sepsis immunology: new ideas/solutions by EGIS as “Editor’s Pick” in Lancet


Comprehending the pathogenesis of sepsis is an important first step in improving patient outcomes. The existing evidence supports a key role of the immune system in sepsis pathogenesis, however, the current understanding of how immunity is modulated in different phases of sepsis remains incomplete at best.

The European Group on Immunology of Sepsis (EGIS) is an expert panel created in 2018 and composed of immunologists, translational researchers, infectious diseases specialists and intensive care medicine physicians (led by J. Bermejo-Martín & I. Rubio). EGIS addresses the above deficits and proposes specific research directions that could rapidly bridge the existing knowledge gaps in the sepsis immunity. The ideas and solutions of EGIS have been just published ahead-of-print (October 17) of Lancet Infectious Diseases, earning an “Editor’s Pick” distinction. Lancet Infect Dis is the highest-rank journal in the field of infectious diseases recognized for providing a global, authoritative, and independent forum for the highest quality infectious diseases research and opinions. Addressing the gaps as delineated in the publication should help the scientists to better understand sepsis physiopathology, offering translational opportunities to improve its prevention, diagnosis, and care.

Dr. M. Osuchowski, head of the Experimental Intensive Care Medicine at LBI Trauma is the second author of this article and simultaneously serves as EGIS member.



Historical evolution of the models explaining pro- and anti-inflammatory responses during sepsis. Models were generated using data obtained from the blood during the sepsis episode. Lines represent prototypical hyperinflammatory (red) versus immune suppressive (blue) disease progression courses with return to immune homeostasis (solid) or pathological immune dysfunction (dashed). CARS: compensatory anti-inflammatory response syndrome. SIRS: systemic inflammatory response syndrome. MARS: mixed antagonist inflammatory response syndrome. PICS: persistent inflammation, immunosuppression, and catabolism syndrome.