Burns, tumors or surgical interventions often result in large scale wounds that challenge the body's ability to regenerate and still represent a huge problem for modern medicine. Technologies that support wound healing and eventually might ease patients' suffering are therefore subject to intensive research.
The group of Peter Dungel researches new applicable treatment approaches and focusses on low level light therapy (LLLT). It has already been shown that light has a dose- and wavelength dependent positive impact on wound healing and chronic pain and leads to a better blood circulation. The use of short-wave light releases among other things the signaling molecule nitric oxide (NO) that regulates for example vasodilatation. Research focus in the area of light therapy is thus put on:
- Examinations on the influence of different wavelengths
- Researching the underlying effect mechanisms
- Reviewing the effects in in vitro and in vivo models
For a project funded by the Austrian Research Promotion Agency (FFG), the group established a cooperation with REPULS Lichtmedizintechnik GmbH, a manufacturer of LLLT devices. The aim of the cooperation is to find a solution to the medical problem of extensive wound healing as well as merge knowledge from cell biology and LED electrical engineering. It could already be shown that LED light reduces tissue necrosis and improves the circulation around the wound area.
Karner L, Drechsler S, Metzger M, Hacobian A, Schädl B, Slezak P, Grillari J, Dungel P (2020). Antimicrobial photodynamic therapy fighting polymicrobial infections - a journey from in vitro to in vivo. Photochem Photobiol Sci. 2020 Oct 1;19(10):1332-1343
Chaudary S, Karner L, Weidinger A, Meixner B, Rieger S, Metzger M, Zipperle J, Dungel P (2020). In vitro effects of 635 nm photobiomodulation under hypoxia/reoxygenation culture conditions. J Photochem Photobiol B. 2020 Aug;209:111935.
Priglinger E, Maier J, Chaudary S, Lindner C, Wurzer C, Rieger S, Redl H, Wolbank S, Dungel P (2018). Photobiomodulation of freshly isolated human adipose tissue-derived stromal vascular fraction cells by pulsed light-emitting diodes for direct clinical application. J Tissue Eng Regen Med. 2018 Jun;12(6):1352-1362
Rohringer S, Holnthoner W, Chaudary S, Slezak P, Priglinger E, Strassl M, Pill K, Mühleder S, Redl H, Dungel P (2017). The impact of wavelengths of LED light-therapy on endothelial cells. Sci Rep. 7(1):10700
Dungel P, Perlinger M, Weidinger A, Redl H, & Kozlov AV. (2015). The cytoprotective effect of nitrite is based on the formation of dinitrosyl iron complexes. Free Radical Biology and Medicine, 89:300-310.
Teuschl A, Balmayor ER, Redl H, van Griensven M, & Dungel P. (2015). Phototherapy With LED Light Modulates Healing Processes in an In Vitro Scratch-Wound Model Using 3 Different Cell Types. Dermatol Surg., 41(2):261-268.
Dungel P, Hartinger J, Chaudary S, Slezak P, Hofmann A, Hausner T, Strassl M, Wintner E, Redl H, & Mittermayr R. (2014). Low Level Light Therapy by LED of Different Wavelength Induces Angiogenesis and Improves Ischemic Wound Healing. Lasers in Surgery and Medicine, 46(10):773-780.
Adamskaya N, Dungel P, Rainer M, Hartinger J, Feichtinger G, Wassermann K, Redl H, & van Griensven M. (2011). Light therapy by blue LED improves wound healing in an excision model in rats. Injury, 42(9):917-921.
Dungel P, Mittermayr R, Haindl S, Osipov A, Wagner C, Redl H, & Kozlov AV. (2008). Illumination with blue light reactivates respiratory activity of mitochondria inhibited by nitric oxide, but not by glycerol trinitrate. Archives of Biochemistry and Biophysics, 471(2):109-115.
Mittermayr R, Osipov A, Piskernik C, Haindl S, Dungel P, Weber C, Vladimirov YA, Redl H, & Kozlov AV. (2007). Blue Laser Light Increases Perfusion of a Skin Flap Via Release of Nitric Oxide from Hemoglobin. Mol Med., 13(1-2):22-29.