Age-related diseases continue to be a major challenge in our modern ageing society, where the number of people over 65 is expected to double within the next 50 years. Age is the most important risk factor for stroke, heart attacks, diabetes and many other chronic diseases. The translation of new findings is hampered by a lack of suitable preclinical models, validated endpoints or regulatory framework.

The main objective of MouseAGE is to form a network of European scientists, clinicians, industrial partners and regulatory affairs experts with multidisciplinary expertise to define best practice on preclinical interventions in mouse models of age and age-related disorders. By producing clear guidelines on issues such as endpoints, methodology and types of measurements as well as models, the translation of findings to the clinics can be accelerated.

Funding agency: COST Action
Project number: MB1402