Marie Curie International Reintegration Grant

Marie Curie International Reintegration Grant (IRG); 2007-2011

Why do they die? Deciphering and quelling the lethal cues of immuno-inflammatory response in sepsis (Grant No: 203685).

 PI : Dr. Marcin F. Osuchowski (LBI Trauma, Austria)

Sepsis continues to be a major life-threatening condition in acute-care patients accounting for thousands of deaths annually, despite rapid progress in health care over the past decades in developed countries. The proposed project addressed the mechanisms and prevention of early mortality (SIRS) in experimental sepsis and its design focused on effective implementation of the "from bench to bedside" philosophy. The project consisted of three aims investigating acute immuno-inflammatory signalling triggered by a septic event.

Overall, the data generated during the project has filled out a number of gaps in understanding in pathophysiological process that lead to death in polymicrobial acute sepsis syndromes, specifically regarding changes occurring in the central nervous system and systemic immuno-inflammatory responses. Additionally, our targeted pre-clinical data aid in design and creation of pointed weapons needed to improve survival of septic patients. Specifically, our findings reinforce the notion that new drugs against sepsis should be offered selectively to carefully pre-defined narrow cohorts of septic patients who have the best chance to benefit. Such tactics have another great advantage – it may spare life of septic subjects whose fragile immuno-inflammatory defence balance could be worsened by unnecessary treatments.