If a great opportunity presents itself, why wait another year? The otherwise biannual TERMIS Winterschool returned in 2018 as a joint event with Interreg, putting mechanobiology in the spotlight. From January 14th to 17th an international group of scientists and students met in Radstadt, Austria, to discuss this innovative field. Focusing on in vitro and in vivo preclinical models the presenters shared experiences all the way from cell sources to specific applications. The last day offered insights in imaging methods.