The research article on enhanced regeneration of critical-size long bone defects using hypertrophic chondrocyte grafts was published in Biomaterials (IF=8). Dr. Jon Bernhard, a Whitaker International Fellow to the LBI together with his colleagues showed the feasibility and promise of differentiated hypertrophic chondrocye grafts to regenerate critical-size femoral defects. They found a rapid bone deposition and integration of hypertophic chondrocyte grafts into the native skeleton, that was superior to the performance of acellular scaffold controls and the grafts prepared in a more traditional, osteoblast-based tissue engineering approach. This is the first research paper published from a very productive collaboration between the group of Prof. Heinz Redl at the Ludwig Boltzmann Institute for Experimental and Clinical Traumatology and Columbia University Laboratory for Stem Cells and Tissue Engineering, directed by Prof. Gordana Vunjak-Novakovic.
Link to the Abstract: Tissue-engineered hypertrophic chondrocyte grafts enhanced long bone repair.